Across TCGA patient cohorts, SDR42E1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDR42E1-associated genes across cancer lineages are VHL, CD49b, and Chk1. Each is linked with SDR42E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDR42E1-to-partner and partner-to-SDR42E1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDR42E1→partner) and Y-score (partner→SDR42E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.025	-2.999	.003	.035	3	2
SKCM	CD49b →	+0.348	+2.923	<.001	<.001	3	1
SKCM	Chk1 →	+0.258	+2.256	.001	.005	3	1
UCEC	FoxM1 →	+0.370	+3.321	.006	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.209	-3.321	.001	.010	3	1
UCEC	Ku80 →	+0.371	+3.335	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

SDR42E1 survival (RNA) · tumor vs normal (RNA) · all SDR42E1 data types