Across TCGA pan-cancer cohorts, SDR16C6P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SDR16C6P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SDR16C6P RNA is repressed in tumor relative to normal tissue. In most cancer types SDR16C6P is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
LUSC and LUAD are the cancer types where SDR16C6P tumor–normal differential expression is most reproducible.