SDK1

Across TCGA pan-cancer cohorts, SDK1 Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated SDK1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SDK1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SDK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, DLBC, and HNSC are the cancer types where SDK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.948	0.420	.002	32	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
HNSC	OS	Median	All	0.174	0.714	<.001	24	view →
SCLC	OS	Median	III,IV	0.342	0.664	.014	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LUSC	DFS	Median	III,IV	0.184	0.662	.016	9	view →
SKCM	OS	Median	II,III,IV	0.427	0.300	.011	9	view →
OV	OS	Median	IV	0.170	0.758	.044	6	view →
KIRC	DFS	Median	All	0.152	0.865	<.001	6	view →
LIHC	DFS	Median	All	0.355	0.554	.017	5	view →
LUAD	DFS	Median	IV	1.000	0.282	.036	4	view →
ESCA	OS	Median	II,III,IV	0.303	0.559	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SDK1–UCEC (DFS)

Open the UCEC breakdown →