SDK1

Across TCGA pan-cancer cohorts, SDK1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SDK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SDK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SDK1 is over-expressed in tumor, although a few such as OV and LUAD show the opposite, repressed pattern.

LSCC, HNSC, and OV are the cancer types where SDK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.554	<.001	8	view →
HNSC	Male	All	+0.342	<.001	6	view →
OV	All	All	−1.082	.017	2	view →
CCRCC	Male	All	+0.325	.037	1	view →
LUAD	Female	All	−0.191	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SDK1–LSCC

Open the LSCC breakdown →