SDK1

Across TCGA patient cohorts, SDK1 mutation is significantly associated with the RNA expression of many other genes, with 7,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDK1-associated genes across cancer lineages are CDC45, GRSF1, and EME1. Each is linked with SDK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SDK1-to-partner and partner-to-SDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by SDK1-low versus SDK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK1→partner) and Y-score (partner→SDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC45 →	+0.494	+1.857	<.001	<.001	3	6
STAD	GRSF1 →	+0.402	+2.218	<.001	<.001	3	6
UCEC	EME1 →	+0.405	+1.040	<.001	.001	3	5
READ	CASP3 →	+0.546	+3.188	.008	.009	3	5
UCEC	PLK1 →	+0.369	+1.145	.007	.003	3	5
STAD	GLOD4 →	+0.413	+2.082	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,219 associations by consensus.

CDC45 by SDK1 expression — UCEC

Explore this box plot interactively →