SDK1

Across TCGA patient cohorts, SDK1 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDK1-associated genes across cancer lineages are c-Kit, ADAR1, and p53. Each is linked with SDK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SDK1-to-partner and partner-to-SDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by SDK1-low versus SDK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK1→partner) and Y-score (partner→SDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	c-Kit →	-0.410	-3.897	.020	<.001	2	4
STAD	ADAR1 →	+0.093	+1.322	.038	.032	3	3
UCEC	p53 →	-0.216	-1.115	.017	.022	3	3
STAD	TIGAR →	+0.307	+1.925	.021	.004	3	3
STAD	YAP_pS127 →	-0.281	-1.584	.007	.017	3	3
UCEC	4E-BP1 →	+0.240	+1.777	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

c-Kit by SDK1 expression — LUSC

Explore this box plot interactively →