SDK1

Across TCGA cell cohorts, SDK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,928 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SDK1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Positive regulation of stem cell population maintenance, and Aerobic electron transport chain. Each is linked with SDK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SDK1-to-partner and partner-to-SDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by SDK1-low versus SDK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK1→partner) and Y-score (partner→SDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.112	+2.012	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.126	+2.412	<.001	<.001	3	12
OVARY	Aerobic electron transport chain →	+0.084	+0.869	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	ATP synthesis coupled electron transport →	+0.105	+1.242	.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Mitochondrial ATP synthesis coupled electron transport →	+0.105	+1.242	.001	.002	3	12
LUNG_SCLC	Regulation of myoblast fusion →	+0.107	+2.170	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,928 associations by consensus.

Negative regulation of myoblast fusion by SDK1 expression — LUNG_SCLC

Explore this box plot interactively →