SDK1

Across TCGA cell cohorts, SDK1 mutation is significantly associated with the RNA expression of many other genes, with 2,200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SDK1-associated genes across cancer lineages are OR4M2, OR2F1, and POLI. Each is linked with SDK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SDK1-to-partner and partner-to-SDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M2 grouped by SDK1-low versus SDK1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDK1→partner) and Y-score (partner→SDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4M2 →	+0.056	+3.193	<.001	.004	3	3
OESOPHAGUS	OR2F1 →	+0.016	+4.392	<.001	.003	3	3
SKIN	POLI →	+0.575	+1.850	.001	.006	3	3
SKIN	L1CAM →	-2.091	-3.169	.001	.006	3	3
LARGE_INTESTINE	THOC1 →	+0.767	+1.566	<.001	<.001	3	3
LARGE_INTESTINE	BBS7 →	+0.632	+1.906	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,200 associations by consensus.

OR4M2 by SDK1 expression — SOFT_TISSUE

Explore this box plot interactively →