Across TCGA pan-cancer cohorts, SDHDP6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SDHDP6’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SDHDP6 RNA is repressed in tumor relative to normal tissue. In most cancer types SDHDP6 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and UCEC are the cancer types where SDHDP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDHDP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.648	<.001	6	view →
KICH	All	All	−0.640	<.001	5	view →
UCEC	All	All	−0.813	<.001	4	view →
LUAD	All	IV	−0.534	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SDHDP6 RNA expression & survival · all SDHDP6 data types