Across TCGA pan-cancer cohorts, SDHD mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SDHD data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SDHD mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SDHD expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, HNSC, and GBM are the cancer types where SDHD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.243	0.698	.021	14	view →
HNSC	DFS	Median	IV	0.963	0.669	.013	7	view →
GBM	OS	Tertile	All	0.462	0.243	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SDHD tumor-vs-normal RNA expression · all SDHD data types