Across TCGA patient cohorts, SDHD RNA expression is significantly associated with the protein abundance of many other proteins, with 10,239 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SDHD-associated proteins across cancer lineages are CUL5, CWF19L2, and FDX1. Each is linked with SDHD in more than 5 cancer types. Because this analysis shows association rather than direction, both SDHD-to-partner and partner-to-SDHD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHD→partner) and Y-score (partner→SDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CUL5 →	+0.330	+0.657	<.001	.007	2	6
HNSC	CWF19L2 →	+0.292	+1.023	<.001	<.001	3	5
OV	FDX1 →	+0.394	+0.736	<.001	<.001	3	4
HNSC	UBE4A →	+0.289	+0.652	<.001	<.001	1	6
COAD	VPS26B →	+0.238	+0.648	<.001	<.001	3	4
BRCA	YAP1_S164 →	+0.717	+0.680	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,239 associations by consensus.

Exploration

SDHD survival (RNA) · tumor vs normal (RNA) · all SDHD data types