Across TCGA patient cohorts, SDHD mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible SDHD-associated genes across cancer lineages are RNU1-52P, RN7SL713P, and BIRC8. Each is linked with SDHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHD-to-partner and partner-to-SDHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHD→partner) and Y-score (partner→SDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-52P →	+0.109	+4.492	<.001	.005	3	2
UCEC	RN7SL713P →	+0.176	+4.279	<.001	.001	3	2
LUAD	BIRC8 →	+0.085	+4.554	<.001	.009	3	1
LUAD	RNA5SP336 →	+0.262	+5.315	<.001	.003	3	1
LUAD	RNA5SP339 →	+0.250	+5.197	<.001	.003	3	1
LUAD	TPMTP3 →	+0.068	+4.888	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Exploration

SDHD survival (RNA) · tumor vs normal (RNA) · all SDHD data types