Across TCGA patient cohorts, SDHD mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SDHD-associated genes across cancer lineages are Osteoblast and Adipocytes. Each is linked with SDHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHD-to-partner and partner-to-SDHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHD→partner) and Y-score (partner→SDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Osteoblast →	+0.043	+3.494	.002	.030	3	1
UCEC	Adipocytes →	+0.028	+3.507	.018	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

SDHD survival (RNA) · tumor vs normal (RNA) · all SDHD data types