Across TCGA cell cohorts, SDHD RNA expression is significantly associated with the go_rna of many other GO terms, with 2,560 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SDHD-associated GO terms across cancer lineages are Pyruvate decarboxylation to acetyl-CoA, Ether catabolic process, and Glycerol ether catabolic process. Each is linked with SDHD in more than 15 cancer types. Because this analysis shows association rather than direction, both SDHD-to-partner and partner-to-SDHD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHD→partner) and Y-score (partner→SDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Pyruvate decarboxylation to acetyl-CoA →	+0.146	+0.922	<.001	<.001	3	16
BREAST	Ether catabolic process →	+0.140	+0.831	.001	<.001	3	11
BREAST	Glycerol ether catabolic process →	+0.140	+0.831	.001	<.001	3	11
PANCREAS	Pteridine-containing compound catabolic process →	+0.161	+0.571	.001	.006	3	11
PANCREAS	Folic acid-containing compound catabolic process →	+0.161	+0.571	.001	.006	3	11
BREAST	Platelet activating factor catabolic process →	+0.140	+0.831	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,560 associations by consensus.

Exploration

SDHD survival (RNA) · tumor vs normal (RNA) · all SDHD data types