Across TCGA pan-cancer cohorts, SDHAF3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDHAF3 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SDHAF3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SDHAF3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where SDHAF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	18	view →
LSCC	DFS	Median	II,III,IV	0.831	0.547	.005	16	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.815	.015	9	view →
HNSC	DFS	Median	III,IV	0.909	1.000	.007	6	view →
GBM	OS	Quartile	All	0.679	0.332	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SDHAF3 tumor-vs-normal RNA expression · all SDHAF3 data types