Across TCGA patient cohorts, SDHAF3 mutation is significantly associated with the RNA expression of many other genes, with 128 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SDHAF3-associated genes across cancer lineages are SPATA17-AS1, SLC16A12-AS1, and SNRPCP19. Each is linked with SDHAF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHAF3-to-partner and partner-to-SDHAF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHAF3→partner) and Y-score (partner→SDHAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPATA17-AS1 →	+0.124	+2.992	<.001	.009	3	1
SKCM	SLC16A12-AS1 →	+0.028	+4.147	<.001	.008	3	1
SKCM	SNRPCP19 →	+0.118	+4.237	<.001	<.001	3	1
SKCM	DSCAM-AS1 →	+0.052	+3.351	<.001	.008	3	1
SKCM	GOLGA2P6 →	+0.015	+4.897	<.001	.002	3	1
SKCM	SPECC1P2 →	+0.104	+4.475	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 128 associations by consensus.

Exploration

SDHAF3 survival (RNA) · tumor vs normal (RNA) · all SDHAF3 data types