SDHAF2

Across TCGA pan-cancer cohorts, SDHAF2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SDHAF2 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SDHAF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SDHAF2 expression acts as an unfavorable survival marker.

CCRCC, UCEC, and PDAC are the cancer types where SDHAF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.790	1.000	.004	16	view →
UCEC	DFS	Quartile	All	0.841	1.000	.033	2	view →
PDAC	DFS	Quartile	All	0.666	0.886	.038	1	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SDHAF2–CCRCC (OS)

Open the CCRCC breakdown →