Across TCGA patient cohorts, SDHAF1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDHAF1-associated genes across cancer lineages are MIR4727, MIR4285, and PANDAR. Each is linked with SDHAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHAF1-to-partner and partner-to-SDHAF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHAF1→partner) and Y-score (partner→SDHAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4727 →	+0.536	+4.551	.003	.009	3	1
UCEC	MIR4285 →	+0.590	+4.473	.004	.005	3	1
UCEC	PANDAR →	+0.064	+4.840	<.001	.003	3	1
UCEC	RNU1-112P →	+0.540	+5.386	<.001	.001	3	1
UCEC	RNA5SP205 →	+0.447	+4.852	<.001	.006	3	1
UCEC	RNU6-739P →	+0.408	+4.852	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

SDHAF1 survival (RNA) · tumor vs normal (RNA) · all SDHAF1 data types