SDHA

Across TCGA pan-cancer cohorts, SDHA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDHA data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SDHA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SDHA expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, CCRCC, and UCEC are the cancer types where SDHA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.899	0.516	.004	23	view →
CCRCC	DFS	Median	II,III,IV	0.592	0.829	.015	8	view →
UCEC	OS	Median	All	0.900	1.000	.005	4	view →
PDAC	DFS	Quartile	III,IV	0.312	0.615	.043	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDHA–LSCC (DFS)

Open the LSCC breakdown →