SDHA

Across TCGA patient cohorts, SDHA mutation is significantly associated with the RNA expression of many other genes, with 5,178 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDHA-associated genes across cancer lineages are ZFYVE19, SZRD1, and CTDP1. Each is linked with SDHA in more than 2 cancer types. Because this analysis shows association rather than direction, both SDHA-to-partner and partner-to-SDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE19 grouped by SDHA-low versus SDHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHA→partner) and Y-score (partner→SDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.365	+1.484	<.001	.004	3	3
UCEC	SZRD1 →	+0.347	+2.222	<.001	<.001	3	3
UCEC	CTDP1 →	+0.315	+2.721	.001	.003	3	3
UCEC	SF3A1 →	+0.428	+2.828	.003	.001	3	3
UCEC	EMC1 →	+0.428	+2.446	<.001	.001	3	3
UCEC	KIF2C →	+0.720	+2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,178 associations by consensus.

ZFYVE19 by SDHA expression — UCEC

Explore this box plot interactively →