SDHA

Across TCGA patient cohorts, SDHA mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDHA-associated genes across cancer lineages are MEK1, Rad50, and Annexin-1. Each is linked with SDHA in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHA-to-partner and partner-to-SDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SDHA-low versus SDHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHA→partner) and Y-score (partner→SDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.329	+1.938	.006	.001	3	2
COAD	Rad50 →	-0.338	-3.144	<.001	.018	3	2
UCEC	Annexin-1 →	+0.439	+2.019	.011	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.205	+2.593	<.001	.006	3	2
UCEC	FoxM1 →	+0.235	+1.938	.005	.001	3	2
UCEC	p27_pT198 →	+0.080	+1.652	.022	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MEK1 by SDHA expression — UCEC

Explore this box plot interactively →