SDHA

Across TCGA cell cohorts, SDHA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,335 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SDHA-associated GO terms across cancer lineages are Meiotic recombination checkpoint signaling, 2-oxoglutarate decarboxylation to succinyl-CoA, and Thalamus development. Each is linked with SDHA in more than 9 cancer types. Because this analysis shows association rather than direction, both SDHA-to-partner and partner-to-SDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic recombination checkpoint signaling grouped by SDHA-low versus SDHA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHA→partner) and Y-score (partner→SDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Meiotic recombination checkpoint signaling →	+0.174	+0.673	<.001	<.001	3	10
BREAST	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.150	+1.026	<.001	<.001	3	10
CNS	Thalamus development →	+0.209	+0.705	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Tricarboxylic acid cycle →	+0.140	+1.419	<.001	<.001	3	9
LARGE_INTESTINE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.090	+0.697	<.001	.001	3	9
BLOOD_Leukemia	Deoxyribonucleoside monophosphate biosynthetic process →	+0.070	+0.576	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,335 associations by consensus.

Meiotic recombination checkpoint signaling by SDHA expression — BREAST

Explore this box plot interactively →