SDHA

Across TCGA cell cohorts, SDHA protein abundance is significantly associated with the go_rna of many other GO terms, with 2,211 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SDHA-associated GO terms across cancer lineages are Transforming growth factor beta production, Positive regulation of response to oxidative stress, and Renal system vasculature development. Each is linked with SDHA in more than 2 cancer types. Because this analysis shows association rather than direction, both SDHA-to-partner and partner-to-SDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transforming growth factor beta production grouped by SDHA-low versus SDHA-high in LARGE_INTESTINE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHA→partner) and Y-score (partner→SDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transforming growth factor beta production →	+0.125	+1.178	.006	.008	3	3
BREAST	Positive regulation of response to oxidative stress →	-0.213	-1.295	<.001	<.001	3	3
BREAST	Renal system vasculature development →	+0.303	+1.694	.004	.001	3	2
BREAST	Kidney vasculature development →	+0.303	+1.694	.004	.001	3	2
LARGE_INTESTINE	Dendrite extension →	-0.121	-1.218	<.001	.002	3	2
LARGE_INTESTINE	Monoatomic anion transmembrane transport →	-0.047	-1.342	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,211 associations by consensus.

Transforming growth factor beta production by SDHA expression — LARGE_INTESTINE

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