SDHA

Across TCGA cell cohorts, SDHA mutation is significantly associated with the RNA expression of many other genes, with 647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SDHA-associated genes across cancer lineages are ZC3H14, RAD51AP1, and TTC33. Each is linked with SDHA in more than 1 cancer types. Because this analysis shows association rather than direction, both SDHA-to-partner and partner-to-SDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3H14 grouped by SDHA-low versus SDHA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDHA→partner) and Y-score (partner→SDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZC3H14 →	+0.400	+3.169	.008	.006	3	2
LARGE_INTESTINE	RAD51AP1 →	+0.555	+2.265	.004	.001	3	2
LARGE_INTESTINE	TTC33 →	+0.562	+3.321	.002	.003	3	2
LARGE_INTESTINE	PDS5A →	+0.617	+4.043	<.001	<.001	3	2
LARGE_INTESTINE	STIL →	+0.548	+3.523	.002	<.001	3	2
LARGE_INTESTINE	VHL →	+0.566	+2.389	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

ZC3H14 by SDHA expression — LARGE_INTESTINE

Explore this box plot interactively →