SDF4

Across TCGA pan-cancer cohorts, SDF4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SDF4 data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SDF4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SDF4 expression acts as an unfavorable survival marker.

KIRC, SKCM, and CESC are the cancer types where SDF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.249	0.805	.010	12	view →
SKCM	OS	Median	IV	0.415	0.861	.014	12	view →
CESC	DFS	Median	All	0.250	0.740	.030	6	view →
LUSC	OS	Median	II,III,IV	0.259	0.732	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SDF4–KIRC (OS)

Open the KIRC breakdown →