SDF4

Across TCGA pan-cancer cohorts, SDF4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDF4 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SDF4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SDF4 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where SDF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.463	0.879	<.001	55	view →
LSCC	DFS	Tertile	All	0.842	0.999	.001	42	view →
HNSC	OS	Tertile	II,III,IV	0.558	0.847	.002	25	view →
PDAC	DFS	Median	II,III,IV	0.535	0.280	.001	22	view →
LUAD	DFS	Quartile	II,III,IV	0.570	1.000	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDF4–CCRCC (OS)

Open the CCRCC breakdown →