SDF4

Across TCGA pan-cancer cohorts, SDF4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SDF4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SDF4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SDF4 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where SDF4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDF4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.715	<.001	9	view →
LSCC	Female	All	+0.611	<.001	8	view →
PDAC	Female	All	+0.345	<.001	5	view →
HNSC	All	IV	+0.280	.005	5	view →
COAD	Female	IV	−0.587	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SDF4–LUAD

Open the LUAD breakdown →