SDF4

Across TCGA patient cohorts, SDF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. LGG shows the largest number of these associations.

The most reproducible SDF4-associated GO terms across cancer lineages are Maintenance of protein location in mitochondrion, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence, and Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Each is linked with SDF4 in more than 22 cancer types. Because this analysis shows association rather than direction, both SDF4-to-partner and partner-to-SDF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of protein location in mitochondrion grouped by SDF4-low versus SDF4-high in LGG.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDF4→partner) and Y-score (partner→SDF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Maintenance of protein location in mitochondrion →	+0.068	+0.458	<.001	<.001	3	23
UVM	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.057	+0.772	<.001	<.001	3	23
TGCT	Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway →	+0.063	+0.584	<.001	<.001	3	20
SCLC	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.126	+0.525	.002	<.001	2	21
THYM	Pulmonary valve morphogenesis →	+0.068	+0.649	<.001	<.001	3	19
SCLC	Positive regulation of exosomal secretion →	+0.104	+0.458	.002	.009	1	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Maintenance of protein location in mitochondrion by SDF4 expression — LGG

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