SDF4

Across TCGA patient cohorts, SDF4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDF4-associated genes across cancer lineages are INPP4B, AMPK_pT172, and ATM. Each is linked with SDF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDF4-to-partner and partner-to-SDF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SDF4-low versus SDF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDF4→partner) and Y-score (partner→SDF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.390	-2.986	.037	.037	3	1
UCEC	AMPK_pT172 →	+0.507	+3.013	.033	.019	3	1
UCEC	ATM →	-0.571	-3.000	.029	.037	3	1
UCEC	Di-Ras3 →	-0.201	-3.000	.019	.037	2	1
UCEC	ERK2 →	+0.372	+3.000	<.001	.037	1	1
UCEC	beta-Catenin →	+0.842	+3.000	.004	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

INPP4B by SDF4 expression — UCEC

Explore this box plot interactively →