SDF4

Across TCGA cell cohorts, SDF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,370 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SDF4-associated GO terms across cancer lineages are Membrane protein proteolysis, Regulation of endosome organization, and Positive regulation of type 2 mitophagy. Each is linked with SDF4 in more than 14 cancer types. Because this analysis shows association rather than direction, both SDF4-to-partner and partner-to-SDF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein proteolysis grouped by SDF4-low versus SDF4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDF4→partner) and Y-score (partner→SDF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Membrane protein proteolysis →	+0.122	+0.890	<.001	<.001	3	15
LIVER	Regulation of endosome organization →	+0.155	+0.822	.003	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of type 2 mitophagy →	+0.126	+0.792	.001	.001	3	14
BONE	Proteoglycan metabolic process →	+0.127	+0.986	<.001	<.001	3	14
BONE	Glycoprotein catabolic process →	+0.214	+0.814	.001	.001	3	14
BONE	Glycoprotein biosynthetic process →	+0.075	+1.181	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,370 associations by consensus.

Membrane protein proteolysis by SDF4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →