SDF4

Across TCGA cell cohorts, SDF4 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SDF4-associated genes across cancer lineages are CLEC2A, OR2L8, and ACER1. Each is linked with SDF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDF4-to-partner and partner-to-SDF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC2A grouped by SDF4-low versus SDF4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDF4→partner) and Y-score (partner→SDF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLEC2A →	+0.733	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2L8 →	+0.046	+4.807	<.001	.006	3	1
LARGE_INTESTINE	ACER1 →	+0.085	+4.145	.002	.001	3	1
LARGE_INTESTINE	H1-6 →	+0.128	+3.509	<.001	.008	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.003	+4.078	<.001	.009	3	1
BLOOD_Leukemia	GML →	+0.062	+4.152	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CLEC2A by SDF4 expression — BLOOD_Myeloma

Explore this box plot interactively →