SDF2L1

Across TCGA pan-cancer cohorts, SDF2L1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SDF2L1 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SDF2L1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SDF2L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

UVM, UCEC, and ACC are the cancer types where SDF2L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.360	0.790	<.001	93	view →
UCEC	DFS	Tertile	All	0.734	0.481	<.001	90	view →
ACC	DFS	Median	All	0.198	0.656	<.001	84	view →
OV	OS	Median	II,III,IV	0.374	0.284	.007	52	view →
LGG	DFS	Median	All	0.783	0.877	<.001	27	view →
SCLC	DFS	Quartile	All	0.783	0.461	.011	25	view →
UCS	DFS	Tertile	IV	0.459	0.938	.024	24	view →
LIHC	OS	Median	III,IV	0.329	0.732	.001	22	view →
READ	OS	Tertile	III,IV	0.505	0.925	.003	19	view →
KIRC	OS	Median	All	0.837	0.906	.004	18	view →
COAD	DFS	Median	II,III,IV	0.396	0.679	.001	18	view →
HNSC	OS	Tertile	All	0.607	0.811	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SDF2L1–UVM (OS)

Open the UVM breakdown →