SDF2

Across TCGA pan-cancer cohorts, SDF2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDF2 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SDF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SDF2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where SDF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.626	0.987	.010	27	view →
PDAC	OS	Quartile	II,III,IV	0.292	0.559	.026	10	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.857	.004	9	view →
LSCC	OS	Quartile	All	0.798	0.974	.006	7	view →
LUAD	DFS	Median	II,III,IV	0.737	0.912	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDF2–CCRCC (OS)

Open the CCRCC breakdown →