SDE2

Across TCGA pan-cancer cohorts, SDE2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDE2 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SDE2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SDE2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SDE2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.650	0.894	.007	18	view →
CCRCC	OS	Median	II,III,IV	0.849	0.610	.005	13	view →
PDAC	DFS	Tertile	IV	0.741	0.199	.024	6	view →
LUAD	OS	Median	II,III,IV	0.565	0.845	.035	4	view →
GBM	DFS	Median	All	0.327	0.203	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDE2–HNSC (DFS)

Open the HNSC breakdown →