SDE2

Across TCGA patient cohorts, SDE2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,660 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SDE2-associated genes across cancer lineages are TFAP4, ADAR, and FLVCR1. Each is linked with SDE2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SDE2-to-partner and partner-to-SDE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SDE2 versus TFAP4 in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDE2→partner) and Y-score (partner→SDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TFAP4 →	+0.610	+0.331	<.001	<.001	3	7
UCEC	ADAR →	+0.645	+0.225	<.001	<.001	3	7
HNSC	FLVCR1 →	+0.645	+0.159	<.001	<.001	3	7
UCEC	GON4L →	+0.526	+0.219	<.001	<.001	3	6
LSCC	TSNAX →	+0.598	+0.311	<.001	<.001	3	6
UCEC	DCAF8 →	+0.614	+0.245	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,660 associations by consensus.

SDE2 vs TFAP4 — BRCA

Explore this scatter interactively →