SDE2

Across TCGA patient cohorts, SDE2 mutation is significantly associated with the RNA expression of many other genes, with 875 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDE2-associated genes across cancer lineages are RNU6-668P, RNA5SP35, and TRAJ27. Each is linked with SDE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDE2-to-partner and partner-to-SDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-668P grouped by SDE2-low versus SDE2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDE2→partner) and Y-score (partner→SDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-668P →	+0.355	+5.539	.002	.004	3	2
COAD	RNA5SP35 →	+0.528	+4.790	<.001	.006	3	2
LUSC	TRAJ27 →	+0.903	+4.602	<.001	.001	3	2
LUSC	MARK2P5 →	+0.071	+4.724	.003	.005	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
BRCA	SPATA31A5 →	+0.006	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 875 associations by consensus.

RNU6-668P by SDE2 expression — CESC

Explore this box plot interactively →