SDE2

Across TCGA patient cohorts, SDE2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDE2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with SDE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SDE2-to-partner and partner-to-SDE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SDE2-low versus SDE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDE2→partner) and Y-score (partner→SDE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.639	+3.189	.013	.010	2	3
UCEC	EGFR_pY1068 →	-0.270	-2.115	.013	.019	3	1
UCEC	A-Raf_pS299 →	-0.164	-3.000	.001	.036	3	1
UCEC	ERK2 →	+0.209	+2.999	.013	.035	3	1
UCEC	Fibronectin →	-0.316	-2.312	.028	.034	3	1
UCEC	Heregulin →	-0.167	-2.459	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by SDE2 expression — UCEC

Explore this box plot interactively →