SDCBP

Across TCGA pan-cancer cohorts, SDCBP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SDCBP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SDCBP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SDCBP is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

KIRP, THCA, and HNSC are the cancer types where SDCBP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SDCBP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.938	<.001	11	view →
THCA	Female	All	−0.821	<.001	11	view →
HNSC	All	III,IV	+0.758	<.001	11	view →
LUAD	All	III,IV	−0.831	<.001	9	view →
LIHC	Male	All	+1.102	<.001	8	view →
KICH	Female	II,III,IV	−1.907	<.001	7	view →
LUSC	Female	All	−1.192	<.001	6	view →
BLCA	Male	All	−0.647	<.001	5	view →
STAD	All	All	+0.478	.001	4	view →
BRCA	All	All	−0.299	<.001	4	view →
ESCA	All	All	+0.957	.010	2	view →
UCEC	All	All	−0.413	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SDCBP–KIRP

Open the KIRP breakdown →