SDC4

Across TCGA patient cohorts, SDC4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,684 significant associations in total. OV shows the largest number of these associations.

The most reproducible SDC4-associated genes across cancer lineages are TCF4, DISC1, and LIMS2. Each is linked with SDC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both SDC4-to-partner and partner-to-SDC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SDC4 versus TCF4 in CCRCC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDC4→partner) and Y-score (partner→SDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TCF4 →	-0.718	-0.315	<.001	<.001	3	7
OV	DISC1 →	-0.722	-0.559	<.001	.003	3	6
OV	LIMS2 →	-0.827	-0.570	.003	.003	3	6
OV	AKT3 →	-1.131	-0.563	<.001	.005	3	5
OV	FAM126A →	-0.741	-0.546	<.001	<.001	3	5
GBM	RNF122 →	-0.639	-0.558	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,684 associations by consensus.

SDC4 vs TCF4 — CCRCC

Explore this scatter interactively →