SDC4

Across TCGA patient cohorts, SDC4 mutation is significantly associated with the RNA expression of many other genes, with 1,408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDC4-associated genes across cancer lineages are ZFP64P1, LINC02758, and CHEK1. Each is linked with SDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDC4-to-partner and partner-to-SDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFP64P1 grouped by SDC4-low versus SDC4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDC4→partner) and Y-score (partner→SDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ZFP64P1 →	+0.039	+4.455	.002	.005	3	2
SKCM	LINC02758 →	+0.151	+5.809	<.001	<.001	3	2
UCEC	CHEK1 →	+0.602	+2.724	.004	.003	3	1
UCEC	DLAT →	+0.580	+3.491	.003	.002	3	1
UCEC	DHX37 →	+0.508	+3.638	<.001	.001	3	1
UCEC	NOCT →	+0.673	+3.815	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,408 associations by consensus.

ZFP64P1 by SDC4 expression — CESC

Explore this box plot interactively →