SDC3

Across TCGA pan-cancer cohorts, SDC3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SDC3 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SDC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SDC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, UCEC, and GBM are the cancer types where SDC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.213	0.443	.015	8	view →
UCEC	DFS	Tertile	All	0.803	1.000	.031	4	view →
GBM	OS	Quartile	All	0.223	0.654	.011	4	view →
LSCC	DFS	Quartile	All	0.975	0.642	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SDC3–PDAC (DFS)

Open the PDAC breakdown →