SDC2

Across TCGA pan-cancer cohorts, SDC2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDC2 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SDC2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SDC2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, GBM, and UCEC are the cancer types where SDC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.919	0.644	.004	22	view →
GBM	OS	Tertile	All	0.299	0.733	.004	12	view →
UCEC	OS	Median	III,IV	0.531	1.000	.030	12	view →
CCRCC	DFS	Tertile	All	1.000	0.619	.032	6	view →
PDAC	OS	Median	All	0.910	0.782	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDC2–HNSC (DFS)

Open the HNSC breakdown →