SDC2

Across TCGA patient cohorts, SDC2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDC2-associated genes across cancer lineages are 14-3-3_beta, INPP4B, and Shc_pY317. Each is linked with SDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDC2-to-partner and partner-to-SDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SDC2-low versus SDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDC2→partner) and Y-score (partner→SDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.113	-2.780	.001	.003	3	2
UCEC	INPP4B →	-0.362	-2.807	.001	.002	3	2
UCEC	Shc_pY317 →	-0.250	-3.087	<.001	<.001	3	2
UCEC	ASNS →	+0.393	+1.662	.002	.011	3	2
UCEC	C-Raf →	+0.178	+2.415	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.239	-3.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by SDC2 expression — UCEC

Explore this box plot interactively →