SDC1

Across TCGA pan-cancer cohorts, SDC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDC1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SDC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SDC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where SDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.716	0.860	.005	19	view →
GBM	DFS	Tertile	All	0.262	0.499	.004	9	view →
LSCC	DFS	Median	All	0.460	0.912	.007	6	view →
HNSC	DFS	Tertile	All	0.991	0.892	.022	6	view →
CCRCC	DFS	Median	III,IV	0.578	0.843	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDC1–PDAC (DFS)

Open the PDAC breakdown →