SDC1

Across TCGA patient cohorts, SDC1 mutation is significantly associated with the RNA expression of many other genes, with 788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDC1-associated genes across cancer lineages are KIAA1841, RPL22P14, and RNU4-14P. Each is linked with SDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDC1-to-partner and partner-to-SDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1841 grouped by SDC1-low versus SDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDC1→partner) and Y-score (partner→SDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIAA1841 →	+0.507	+2.658	.003	.005	3	2
UCEC	RPL22P14 →	+0.116	+2.788	<.001	<.001	3	2
UCEC	RNU4-14P →	+0.382	+2.331	<.001	.002	3	2
BLCA	MIR6133 →	+0.201	+4.433	<.001	.007	3	2
SKCM	HTRA2 →	+0.531	+3.379	.001	.005	3	2
SKCM	DUX4L16 →	+0.013	+4.315	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

KIAA1841 by SDC1 expression — UCEC

Explore this box plot interactively →