SDC1

Across TCGA patient cohorts, SDC1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDC1-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and JNK_pT183_Y185. Each is linked with SDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDC1-to-partner and partner-to-SDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by SDC1-low versus SDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDC1→partner) and Y-score (partner→SDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.352	+2.584	.014	.011	3	1
UCEC	A-Raf_pS299 →	-0.199	-2.459	<.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-2.321	.030	.034	3	1
UCEC	Ku80 →	+0.247	+1.887	.025	.031	3	1
UCEC	MEK1 →	+0.466	+3.700	.006	.001	3	1
UCEC	p21 →	+0.183	+2.820	.041	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4G by SDC1 expression — UCEC

Explore this box plot interactively →