Across TCGA pan-cancer cohorts, SDAD1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDAD1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SDAD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SDAD1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

OV, BLCA, and STAD are the cancer types where SDAD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.010	0.844	<.001	36	view →
BLCA	DFS	Median	II,III,IV	0.865	0.315	.006	30	view →
STAD	OS	Median	All	0.251	0.734	.001	21	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SDAD1 tumor-vs-normal RNA expression · all SDAD1 data types