Across TCGA patient cohorts, SDAD1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SDAD1-associated genes across cancer lineages are p62 Lck ligand, Caspase-8, and ACVRL1. Each is linked with SDAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SDAD1-to-partner and partner-to-SDAD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDAD1→partner) and Y-score (partner→SDAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.352	+2.710	.004	.003	3	2
UCEC	Caspase-8 →	-0.296	-2.584	.002	.001	3	2
UCEC	ACVRL1 →	-0.107	-3.156	.041	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.807	.002	<.001	3	1
UCEC	Ku80 →	+0.238	+1.335	.008	.046	3	1
UCEC	MEK1 →	+0.380	+3.169	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

SDAD1 survival (RNA) · tumor vs normal (RNA) · all SDAD1 data types