SCYL3

Across TCGA cell cohorts, SCYL3 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCYL3-associated genes across cancer lineages are UNC0642, AZD5438, and LCL161. Each is linked with SCYL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCYL3-to-partner and partner-to-SCYL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC0642 grouped by SCYL3-low versus SCYL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCYL3→partner) and Y-score (partner→SCYL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC0642 →	+0.226	+2.658	.015	.043	3	1
LARGE_INTESTINE	AZD5438 →	+0.493	+2.777	.046	.038	3	1
LARGE_INTESTINE	LCL161 →	+0.356	+2.646	.028	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.390	+2.678	.013	.037	3	1
LARGE_INTESTINE	Bromosporine →	+0.352	+2.649	.041	.046	3	1
LARGE_INTESTINE	Quizartinib →	+0.354	+2.652	.028	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

UNC0642 by SCYL3 expression — LARGE_INTESTINE

Explore this box plot interactively →