SCYL2

Across TCGA patient cohorts, SCYL2 mutation is significantly associated with the RNA expression of many other genes, with 3,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCYL2-associated genes across cancer lineages are RNA5SP360, HMGN1P31, and RNU7-74P. Each is linked with SCYL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCYL2-to-partner and partner-to-SCYL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP360 grouped by SCYL2-low versus SCYL2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCYL2→partner) and Y-score (partner→SCYL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP360 →	+0.148	+3.932	<.001	.009	3	5
BLCA	HMGN1P31 →	+0.083	+4.618	<.001	.005	3	3
BLCA	RNU7-74P →	+0.487	+5.307	<.001	.001	3	3
LUSC	RNU6-796P →	+0.413	+4.285	<.001	<.001	3	3
COAD	KRTAP19-5 →	+0.223	+5.547	<.001	.002	3	3
UCEC	TMEM269 →	+0.188	+1.676	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,269 associations by consensus.

RNA5SP360 by SCYL2 expression — LUSC

Explore this box plot interactively →